OPTIMAL DESIGNS FOR POPULATION PHARMACOKINETIC STUDIES OF ORAL ARTESUNATE IN PATIENTS WITH UNCOMPLICATED FALCIPARUM MALARIA

Optimal designs for population pharmacokinetic studies of oral artesunate in patients with uncomplicated falciparum malaria

Abstract Background Currently, population pharmacokinetic (PK) studies of anti-malarial drugs are designed primarily by the logistical and ethical constraints of taking blood samples from patients, and the statistical models that are fitted to the data are not formally considered.This could lead to imprecise estimates of the target PK parameters, a

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Ambivalent Sexism as a Mediator for Sex Role Orientation and Gender Stereotypes in Romantic Relationships: A Study in Turkey

The present study examined the mediating effects of ambivalent sexism (hostile and benevolent) in the relationship between sex role orientation (masculinity and femininity) and gender stereotypes (dominance CHEER UP BUTTERCUP and assertiveness) in college students.The variables were measured using the Bem Sex Role Inventory (BSRI), the Ambivalent S

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The role of extra-familial factors in adolescence for the association between out-of-home care and adult psychiatric disorders-A birth cohort study.

BackgroundPsychiatric disorders are a substantial public health concern, and childhood adversity a well-known risk factor for it.Investigating gender differences in vulnerability and resilience processes following out-of-home care (OHC) as proxy for childhood adversity can help map opportunities for the prevention of psychiatric disorders.MethodsWe

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